Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 4.889


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_74815233-0.496.3e-02Click!
FOSL1chr11_-_654244360.477.6e-02Click!
FOSBchr19_+_50663089-0.401.4e-01Click!
JUNDchr19_-_182534130.155.8e-01Click!
JUNBchr19_+_127632850.136.5e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_59593591 19.374 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr17_-_37022465 18.628 NM_005557
KRT16
keratin 16
chr3_+_11153778 17.948 NM_001098213
HRH1
histamine receptor H1
chr9_-_90456824 16.721 NM_001100111
LOC286238
hypothetical protein LOC286238
chr5_+_150000394 15.891 NM_001109974
NM_007286
SYNPO

synaptopodin

chr21_+_29439768 15.106 C21orf7
chromosome 21 open reading frame 7
chr13_-_35327798 14.862 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr1_+_221955876 14.856 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr8_+_22900863 14.800 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr6_+_47774247 14.267 NM_153838
GPR115
G protein-coupled receptor 115
chr11_-_102219450 14.162 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr12_-_68369322 13.410 NM_152439
BEST3
bestrophin 3
chr7_+_72883128 13.317 NM_001305
CLDN4
claudin 4
chr1_+_17719405 13.240 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr17_-_36469869 13.172 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr17_+_21131940 13.082 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr18_+_19947314 12.967 TTC39C
tetratricopeptide repeat domain 39C
chr13_+_77007809 12.358 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr3_-_11585264 12.226 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr5_+_140848905 12.181 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr14_-_104507862 11.939 AHNAK2
AHNAK nucleoprotein 2
chr12_+_13240868 11.880 NM_001423
EMP1
epithelial membrane protein 1
chr8_-_38505331 11.527 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr5_+_147562531 11.476 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr17_-_36996611 11.302 NM_000526
KRT14
keratin 14
chr12_-_51173238 11.236 NM_005554
KRT6A
keratin 6A
chr20_-_17487480 11.171 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr3_+_57069508 11.137 NM_181727
SPATA12
spermatogenesis associated 12
chr14_+_95792299 10.979 NM_000710
BDKRB1
bradykinin receptor B1
chr4_+_120276386 10.904 NM_016599
MYOZ2
myozenin 2
chr7_-_135083906 10.555 NM_205855
FAM180A
family with sequence similarity 180, member A
chr15_+_38849450 10.466 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr15_-_68781662 10.433 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr19_-_43955984 10.406 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr4_-_122304925 9.969 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr11_+_12265022 9.962 NM_032867
MICALCL
MICAL C-terminal like
chr1_-_36589744 9.819


chr2_-_73170290 9.774 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr1_-_115682374 9.767 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr9_+_676640 9.751


chr15_-_53996597 9.545 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr1_-_151788341 9.342 NM_002960
S100A3
S100 calcium binding protein A3
chr19_-_40711034 9.302 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chrX_+_99786044 9.212 SRPX2
sushi-repeat containing protein, X-linked 2
chr1_+_151270301 9.188 NM_003125
SPRR1B
small proline-rich protein 1B
chr14_+_20537253 9.148 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr16_+_56219802 9.135 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_+_13240983 8.954 EMP1
epithelial membrane protein 1
chr1_+_34993234 8.912 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr1_-_108032645 8.847 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr4_+_35959638 8.804 NM_001136536
DTHD1
death domain containing 1
chr10_-_88720908 8.779 LOC100133190
hypothetical LOC100133190
chr1_-_221920023 8.738 NM_001143962
CAPN8
calpain 8
chrX_+_99785818 8.737 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr10_-_105228986 8.614 NM_001129742
CALHM3
calcium homeostasis modulator 3
chr6_+_31190505 8.609 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr11_-_119499188 8.601 TRIM29
tripartite motif containing 29
chr12_+_13240987 8.588 EMP1
epithelial membrane protein 1
chr1_-_117554999 8.536 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr5_-_149473127 8.450 NM_005211
CSF1R
colony stimulating factor 1 receptor
chr18_+_19706979 8.438 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr7_-_16811131 8.344 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr10_-_90601655 8.343 NM_144590
ANKRD22
ankyrin repeat domain 22
chr12_-_15706340 8.307 EPS8
epidermal growth factor receptor pathway substrate 8
chr2_+_36777336 8.279 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr16_-_2848106 8.160 NM_022119
PRSS22
protease, serine, 22
chr1_+_34997928 8.152 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr11_+_58146721 8.100 NM_000614
CNTF
ciliary neurotrophic factor
chr6_-_169392771 7.944


chr15_-_38417564 7.935 C15orf52
chromosome 15 open reading frame 52
chr16_+_65868913 7.811 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_-_76676110 7.793 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr5_-_54317102 7.527 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr13_-_37070862 7.501 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr20_-_35586366 7.469 NM_001167823
BLCAP
bladder cancer associated protein
chr1_-_111908085 7.410 NM_001081976
ADORA3
adenosine A3 receptor
chr1_-_150564302 7.392 NM_002016
FLG
filaggrin
chr3_+_161877640 7.268 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr4_+_146820805 7.194 NM_001080531
C4orf51
chromosome 4 open reading frame 51
chr1_-_28392966 7.100 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr16_+_70117523 7.088 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr17_-_7434113 7.057 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr1_-_221919982 7.031 CAPN8
calpain 8
chr10_+_88770025 7.022 NM_001146157
FAM25A
family with sequence similarity 25, member A
chr11_-_128399218 6.959 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr17_-_36928604 6.828 NM_002275
KRT15
keratin 15
chr3_-_127258299 6.805 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr16_-_73859451 6.720 NM_001170715
BCAR1
breast cancer anti-estrogen resistance 1
chr1_+_81544432 6.630 LPHN2
latrophilin 2
chr11_-_102331643 6.629 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr11_+_20005704 6.617 NAV2
neuron navigator 2
chr10_+_24795446 6.615 KIAA1217
KIAA1217
chr9_-_34652629 6.577 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr10_+_24795465 6.536 KIAA1217
KIAA1217
chr15_+_65245546 6.512 NM_001145104
SMAD3
SMAD family member 3
chr11_-_101906640 6.496 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr19_-_56164628 6.439 NM_002774
KLK6
kallikrein-related peptidase 6
chr2_-_202271598 6.422 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr1_+_151147646 6.275 NM_005547
IVL
involucrin
chr19_-_56204615 6.243 NM_012315
KLK9
kallikrein-related peptidase 9
chr10_+_47867667 6.207 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr11_-_123353607 6.172 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr1_+_181421796 6.074 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr3_-_150578207 5.948 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr11_-_102174102 5.942 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr18_-_26996742 5.917 NM_004948
NM_024421
DSC1

desmocollin 1

chr2_+_219180862 5.901 PLCD4
phospholipase C, delta 4
chr11_-_102174032 5.901 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr19_+_43971689 5.896 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr2_-_18634257 5.877 NM_001002006
NM_033253
NT5C1B-RDH14
NT5C1B

NT5C1B-RDH14 readthrough
5'-nucleotidase, cytosolic IB

chr3_-_188936941 5.836 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr14_+_51025604 5.813 NM_001042481
FRMD6
FERM domain containing 6
chr15_+_38319326 5.796 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr19_-_50977485 5.792 DMPK
dystrophia myotonica-protein kinase
chr1_+_40508336 5.752 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_+_181421984 5.720 LAMC2
laminin, gamma 2
chr6_+_41712907 5.712 MDFI
MyoD family inhibitor
chr18_-_45630154 5.705 MYO5B
myosin VB
chr7_+_1543644 5.669 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr3_-_48576204 5.563 NM_033199
UCN2
urocortin 2
chr22_-_41357380 5.518


chr4_-_152366970 5.495 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr8_-_72431274 5.386 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr6_+_47732181 5.374 NM_153839
GPR111
G protein-coupled receptor 111
chr18_+_50646616 5.350 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr3_+_185520744 5.282 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr2_+_202379442 5.271 NM_139158
CDK15
cyclin-dependent kinase 15
chr11_-_8695974 5.260 ST5
suppression of tumorigenicity 5
chr1_+_151223180 5.206 NM_005987
SPRR1A
small proline-rich protein 1A
chr20_+_19903778 5.187 RIN2
Ras and Rab interactor 2
chr18_+_59295123 5.178 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr4_+_661710 5.056 NM_002477
MYL5
myosin, light chain 5, regulatory
chr5_+_59819761 5.045 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr16_-_30983909 5.025 NM_001172669
NM_001172670
ZNF668

zinc finger protein 668

chr5_+_36644187 4.993 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_46601687 4.982 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr6_-_152744143 4.968 SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_+_69055208 4.952 NM_019617
GKN1
gastrokine 1
chr2_+_233605625 4.925 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr14_+_62740878 4.912 NM_020663
RHOJ
ras homolog gene family, member J
chr2_+_113591940 4.904 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr4_-_54119159 4.886 NM_032622
LNX1
ligand of numb-protein X 1
chr1_+_150753601 4.855 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr5_+_73145098 4.838 RGNEF
190 kDa guanine nucleotide exchange factor
chr12_-_90097384 4.830 NM_133503
DCN
decorin
chr10_+_118177371 4.799 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr11_-_62213946 4.798 NM_203422
LRRN4CL
LRRN4 C-terminal like
chr9_-_129381086 4.782 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr4_-_151990061 4.779 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr3_+_190147633 4.759 TPRG1
tumor protein p63 regulated 1
chr21_+_25856311 4.748 MIR155HG
MIR155 host gene (non-protein coding)
chrX_-_33139349 4.720 NM_004006
DMD
dystrophin
chr1_-_159325709 4.712 PVRL4
poliovirus receptor-related 4
chr4_+_76700281 4.700 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr5_+_35892747 4.678 NM_002185
IL7R
interleukin 7 receptor
chr4_-_100575313 4.644 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr12_+_106498763 4.635 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr16_-_30032330 4.620 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr19_-_50977592 4.613 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr2_+_166034402 4.611 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr9_-_90983501 4.603 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr6_+_108593907 4.598 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr17_-_53335748 4.587 NM_017949
CUEDC1
CUE domain containing 1
chr2_+_169634330 4.538 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr5_-_59819642 4.520 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_+_185521139 4.509 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr12_-_105057940 4.504 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr22_-_43986896 4.449 KIAA0930
KIAA0930
chr15_+_39918302 4.440 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chr9_+_35663852 4.433 NM_001216
CA9
carbonic anhydrase IX
chr3_-_150578148 4.432 TM4SF1
transmembrane 4 L six family member 1
chr6_+_30964441 4.421 NM_013994
DDR1
discoidin domain receptor tyrosine kinase 1
chr3_-_197549640 4.389 NM_138461
TM4SF19
transmembrane 4 L six family member 19
chr19_-_50977586 4.387 DMPK
dystrophia myotonica-protein kinase
chr19_-_60573552 4.335 NM_000641
IL11
interleukin 11
chr3_+_101720753 4.327 TMEM45A
transmembrane protein 45A
chr20_+_34206070 4.321 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr3_-_197549588 4.309 TM4SF19
transmembrane 4 L six family member 19
chr8_-_143848225 4.232 NM_177458
LYNX1
Ly6/neurotoxin 1
chrX_-_19598912 4.226 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_181422016 4.223 LAMC2
laminin, gamma 2
chr10_-_48877824 4.222 NM_001137556
NM_001137549
NM_001137548
FAM25B
FAM25G
FAM25C
family with sequence similarity 25, member B
family with sequence similarity 25, member G
family with sequence similarity 25, member C
chr3_+_64645819 4.188 LOC100507098
hypothetical LOC100507098
chr3_-_150578103 4.186 TM4SF1
transmembrane 4 L six family member 1
chr17_-_37034288 4.174 NM_000422
KRT17
keratin 17
chr1_+_24518501 4.133 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr4_+_40032146 4.113 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr11_-_62213577 4.111 LRRN4CL
LRRN4 C-terminal like
chr9_-_116920232 4.110 NM_002160
TNC
tenascin C
chr10_-_116241572 4.088


chr1_+_151025376 4.062 NM_178353
LCE1E
late cornified envelope 1E
chr10_-_31328426 4.049 NM_001143769
ZNF438
zinc finger protein 438
chr10_-_62002672 4.047 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_+_74462226 4.026 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr15_+_84021271 4.024 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr13_-_85271329 4.017 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr13_+_96592051 3.995 MBNL2
muscleblind-like 2 (Drosophila)
chr3_-_58175437 3.960 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_+_24518398 3.932 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr19_-_48661563 3.927 NM_014400
LYPD3
LY6/PLAUR domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.65 1.83e-03 GO:0009888 tissue development
1.30 2.83e-03 GO:0048856 anatomical structure development
1.31 5.15e-03 GO:0048731 system development
1.38 1.29e-02 GO:0048513 organ development
1.58 1.55e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 1.37e-03 GO:0005576 extracellular region
1.48 8.61e-03 GO:0044421 extracellular region part
1.37 1.88e-02 GO:0005856 cytoskeleton
5.10 3.05e-02 GO:0001533 cornified envelope
2.49 3.31e-02 GO:0044449 contractile fiber part
1.84 3.45e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.50 2.50e-03 GO:0030414 peptidase inhibitor activity
2.55 2.54e-03 GO:0004866 endopeptidase inhibitor activity
2.45 5.65e-03 GO:0061135 endopeptidase regulator activity
2.89 1.45e-02 GO:0004867 serine-type endopeptidase inhibitor activity
1.85 1.53e-02 GO:0004175 endopeptidase activity
1.14 1.85e-02 GO:0005515 protein binding
2.17 3.11e-02 GO:0061134 peptidase regulator activity